Completed Enrollment

A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease

I9X-MC-MTAE -

The purpose of this study is to assess the safety, tolerability and effect of study drug LY3372689 in participants with early symptomatic Alzheimer's Disease.

Trial Summary

Age Range
60 - 85 years
Conditions the trial is for
Alzheimer's Disease
What the trial is testing?
LY3372689
Could I receive a Placebo?
Yes
Enrollment Goal
330
Trial Dates
Sep 16, 2021 - Aug 2024
How long will I be in the trial?
Your participation could last up to 137 weeks (maximum total study duration) and include up to 31 visits to the study center.
Trial Phase
II

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have gradual and progressive changes in memory for at least 6 months

  • Participants must have MMSE score of 22 to 30 (inclusive) at baseline

  • Participants must meet 18F flortaucipir PET scan (central read) criteria

  • Participants must have a family member or close friend who is with the participant in study appointments in person or by telephone

  • Male participants must agree to use effective contraception

Participants Must Not:

  • Participants must not have contraindication to MRI or PET scans

  • Participants must not receive current treatment with immunoglobulin G (IgG) therapy

  • Participants must not have cancer within the last 5 years

  • Participants must not have history of hepatitis B or Hepatitis C

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Clinical Trial Resources

Alzheimer’s Disease and Memory Loss Research Studies

To learn more about Alzheimer’s, memory loss and clinical trials being carried out in this area, visit our Alzheimer’s Disease Research page.

Learn More

Neurodegenerative Disease Research

To learn more about neurodegenerative diseases and clinical trials being carried out in the area, visit our Neurodegenerative Disease Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.