Completed Enrollment

A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes (SURPASS-EARLY)

I8F-MC-GPHE -

This study aims to investigate the efficacy and safety of tirzepatide in participants with type 2 diabetes (T2D) compared to other existing treatment options when treatment is initiated early.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Type 2 Diabetes
What the trial is testing?
Antihyperglycemic medication, Tirzepatide
Could I receive a Placebo?
No
Enrollment Goal
780
Trial Dates
Aug 1, 2022 - Nov 2027
How long will I be in the trial?
Your participation could last about 215 weeks and may include up to 26 visits to the study center.
Trial Phase
IV

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have been diagnosed with type 2 diabetes within the last 4 years

  • Participants must have glycated hemoglobin (HbA1c) value ≥ 7.0% and ≤9.5%

  • Participants must have been on a stable metformin treatment for at least 3 months before entering the study

Participants Must Not:

  • Participants must not have type 1 diabetes mellitus (T1DM)

  • Participants must not have a history of acute or chronic inflammation of the pancreas

  • Participants must not have diabetic eye disease

  • Participants must not have had heart disease or other heart conditions like heart failure, cerebrovascular stroke

  • Participants must not have been taking weight loss drugs, including over-the-counter medications during the last 3 months

  • Participants must not have received any injectable GLP-1 receptor agonists or insulin prior to screening

Lilly Trial Alerts

Not the right fit? Sign up to receive updates about new trials that are listed or when a new trial site begins enrolling near you.

Clinical Trial Resources

Diabetes Research

To learn more about diabetes and clinical trials being carried out in this area, visit our Diabetes Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.