Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss (A4)

H8A-MC-LZAZ -

The purpose of this study is to test whether an investigational drug called solanezumab can slow the progression of memory problems associated with brain amyloid (protein that forms plaques in the brains of people with Alzheimer Disease [AD]).

Trial Summary

Age Range
65 - 85 years
Conditions the trial is for
Alzheimer's Disease
What the trial is testing?
Solanezumab (LY2062430)
Could I receive a Placebo?
Yes
Enrollment Goal
1169
Trial Dates
Feb 28, 2014 - Jun 8, 2023
How long will I be in the trial?
Your participation could last approximately 4 1/2 years and include 66 visits to the study center.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participant must have a study partner that is willing to participate as a source of information and has at least weekly contact with the participant (contact can be in-person, via telephone or electronic communication)

  • Participant must have good vein access, such that intravenous (IV) drug delivery or multiple blood draws would be able to be obtained

Participants Must Not:

  • Participant must not be receiving a prescription acetylcholinesterase inhibitor (AChEI) and/or memantine

  • Participant must not have a history within the last 5 years of a serious infectious disease affecting the brain (including neurosyphilis, meningitis, or encephalitis) or head trauma resulting in longer than expected loss of consciousness

  • Participant must not have a history within the past 2 years of major depression or bipolar disorder

  • Participant must not have a history within the past 5 years of chronic alcohol or drug abuse/dependence

  • Participant must not have a known history of human immunodeficiency virus (HIV)

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Clinical Trial Resources

Alzheimer’s Disease and Memory Loss Research Studies

To learn more about Alzheimer’s, memory loss and clinical trials being carried out in this area, visit our Alzheimer’s Disease Research page.

Learn More

Neurodegenerative Disease Research

To learn more about neurodegenerative diseases and clinical trials being carried out in the area, visit our Neurodegenerative Disease Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.