Enrolling

A Donanemab (LY3002813) Prevention Study in Participants With Alzheimer's Disease (TRAILBLAZER-ALZ 3)

I5T-MC-AACM -

The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD).

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See if You May Qualify

Answer a few questions to see if you meet key criteria for this study.

Trial Summary

Age Range
65 - 80 years
Conditions the trial is for
Alzheimer's Disease
What the trial is testing?
Donanemab, LY3002813
Could I receive a Placebo?
Yes
Enrollment Goal
2600
Trial Dates
Aug 27, 2021 - Nov 2027
How long will I be in the trial?
Your participation could last up to 186 weeks + and include up to 17 visits to the study center.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have a reliable study partner with whom they have regular contact and who can be contacted during the study

  • Participants in the United States must be 65 to 80 years old. Participants in Japan must be 55 to 80 years old

Participants Must Not:

  • Participants must not have been diagnosed with a condition that causes memory or thinking problems such as dementia or early dementia, or a significant disease of the brain

  • Participants must not have a serious medical condition, such as a neurologic or psychiatric illness, or a history of a serious medical condition, including certain types of cancers

  • Participants must not have a history of severe drug allergies or hypersensitivity reactions

  • Participants must not have any allergies to Donanemab or its components

  • Participants must not have certain health conditions that prevent them from getting an MRI

  • Participants must not have certain abnormal lab or MRI values at screening

  • Participants must not have taken certain medicines or had certain treatments

  • Participant must not be pregnant or can become pregnant during the study (for example, have not had menopause or ovary removal)

Lilly Trial Alerts

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Take the Next Step

Complete this Lilly Trial Connect questionnaire to find out if this clinical trial may be a good fit for you, or a loved one.
When you press Start Lilly Trial Connect, you will answer questions about relevant medical conditions and treatment history. The answers will be compared to some of the key criteria for this trial, called inclusion and exclusion criteria.

If your responses show that the trial may be a good fit, you can:
  • Select which clinical trial site works best for you.
  • Share your details and questionnaire directly with site(s) that allow this.
  • Get contact details for the site(s) of your choice.

Completing the Trial Connect questionnaire doesn’t mean that you will be enrolled in a study. There may be more eligibility criteria for the study which are assessed by the Lilly clinical team.

Clinical Trial Resources

Alzheimer’s Disease and Memory Loss Research Studies

To learn more about Alzheimer’s, memory loss and clinical trials being carried out in this area, visit our Alzheimer’s Disease Research page.

Learn More

Neurodegenerative Disease Research

To learn more about neurodegenerative diseases and clinical trials being carried out in the area, visit our Neurodegenerative Disease Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.