A Study of LY3471851 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC) (INSTRUCT-UC)

The reason for this study is to determine if the study drug LY3471851 is safe and effective in adult participants with active moderate-to-severe ulcerative colitis (UC).

Trial Summary

Age Range
18 - 75 years
Conditions the trial is for
Ulcerative Colitis
What the trial is testing?
LY3471851
Could I receive a Placebo?
Yes
Enrollment Goal
81
Trial Dates
Mar 22, 2021 - Aug 9, 2022
How long will I be in the trial?
The study will last about 52 weeks.
Trial Phase
II

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have a diagnosis of ulcerative colitis for at least 3 months before the planned start date for the study medications

  • Participants must have moderately or severely active ulcerative colitis at the start of the study

  • Participants must have had unsatisfactory results with or were unable to take other therapies for UC

  • Participants who are female must meet birth control requirements in order to participate in the study

Participants Must Not:

  • Participants must not have other types of inflammatory bowel disease, such as Crohn's disease or indeterminate colitis (also known as inflammatory bowel disease-unclassified)

  • Participants must not have had surgery in the past in order to remove part of the colon

  • Participants must not have had a recent complication of a blood clot or be on an anticoagulant.

  • Participants must not have received certain types of medications for inflammatory diseases in the past. The study doctor can determine if you have received these when they speak with you at the screening visit

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