Completed Enrollment

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer (LIBRETTO-531)

J2G-MC-JZJB -

The reason for this study is to see if the study drug selpercatinib is safe and more effective compared to a standard treatment in participants with rearranged during transfection (RET)-mutant medullary thyroid cancer (MTC) that cannot be removed by surgery or has spread to other parts of the body.

Trial Summary

Age Range
≥12 years
Conditions the trial is for
Medullary Thyroid Cancer
What the trial is testing?
Selpercatinib, Cabozantinib, Vandetanib
Could I receive a Placebo?
No
Enrollment Goal
291
Trial Dates
Feb 11, 2020 - Feb 2026
How long will I be in the trial?
Your participation in this trial could last approximately 30 months, depending on your cancer type and how you and your tumor respond.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have medullary thyroid cancer that is not able to be removed by surgery or has spread to other places in the body, has not been treated with certain medications previously, and has evidence on imaging studies that the cancer has gotten bigger in the previous 14 months

  • Participants must have evidence that their cancer is caused by a mutation in the RET gene

  • Participants must be in fair to good general health and not have another serious medical condition

  • Participants must be willing to use highly effective contraception during the study

Participants Must Not:

  • Participants must not have cancer that has spread to the brain or spinal cord that is causing symptoms

  • Participants must not have a heart condition that puts you at risk for abnormal heart rhythms

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