Recruiting

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

J2G-MC-JZJB - ClinicalTrials.gov - NCT04211337

The reason for this study is to see if the study drug selpercatinib is safe and more effective compared to a standard treatment in participants with rearranged during transfection (RET)-mutant medullary thyroid cancer (MTC) that cannot be removed by surgery or has spread to other parts of the body.
How long will I be in the trial?
Your participation in this trial could last approximately 30 months, depending on your cancer type and how you and your tumor respond.
Email
Recruiting

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

J2G-MC-JZJB - ClinicalTrials.gov - NCT04211337

The reason for this study is to see if the study drug selpercatinib is safe and more effective compared to a standard treatment in participants with rearranged during transfection (RET)-mutant medullary thyroid cancer (MTC) that cannot be removed by surgery or has spread to other parts of the body.
How long will I be in the trial?
Your participation in this trial could last approximately 30 months, depending on your cancer type and how you and your tumor respond.
Email

Key Requirements

Age :

12+

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

12+

Sex

All

Participants must

Participants must have medullary thyroid cancer that is not able to be removed by surgery or has spread to other places in the body, has not been treated with certain medications previously, and has evidence on imaging studies that the cancer has gotten bigger in the previous 14 months

Participants must have evidence that their cancer is caused by a mutation in the RET gene

Participants must be in fair to good general health and not have another serious medical condition

Participants must be willing to use highly effective contraception during the study

Participants must NOT

Participants must not have cancer that has spread to the brain or spinal cord that is causing symptoms

Participants must not have a heart condition that puts you at risk for abnormal heart rhythms

Trial Summary

Conditions the trial is for

Head and Neck Cancer, Pediatric Solid Tumors

What the trial is testing?

Selpercatinib, Cabozantinib, Vandetanib

Could I receive a Placebo?

no

Enrollment Goal

400

Trial Dates

February 2020 - September 2024

Trial Phase

3

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Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

12+

Sex

All

Participants must

Participants must have medullary thyroid cancer that is not able to be removed by surgery or has spread to other places in the body, has not been treated with certain medications previously, and has evidence on imaging studies that the cancer has gotten bigger in the previous 14 months

Participants must have evidence that their cancer is caused by a mutation in the RET gene

Participants must be in fair to good general health and not have another serious medical condition

Participants must be willing to use highly effective contraception during the study

Participants must NOT

Participants must not have cancer that has spread to the brain or spinal cord that is causing symptoms

Participants must not have a heart condition that puts you at risk for abnormal heart rhythms

Trial Summary

Conditions the trial is for

Head and Neck Cancer, Pediatric Solid Tumors

What the trial is testing?

Selpercatinib, Cabozantinib, Vandetanib

Could I receive a Placebo?

no

Enrollment Goal

400

Trial Dates

February 2020 - September 2024

Trial Phase

3

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Trial Locations

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Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?