Enrolling

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma

The study's purpose is to see if the drug abemaciclib is safe and effective in combination with temozolomide and irinotecan (Part A) and abemaciclib in combination with temozolomide (Part B) in pediatric and young adult participants with relapsed/refractory solid tumors.

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See if You May Qualify

Answer a few questions to see if you meet key criteria for this study.

Trial Summary

Age Range
≤21 years
Conditions the trial is for
Advanced Solid Tumors
What the trial is testing?
Abemaciclib, Irinotecan, Temozolomide, Dinutuximab and GM-CSF
Could I receive a Placebo?
No
Enrollment Goal
117
Trial Dates
Nov 9, 2020 - Oct 2028
How long will I be in the trial?
Your participation in this trial could last up to 24 months, depending on your cancer type and how you and your tumor respond
Trial Phase
II

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have a solid tumor that came back or did not improve with treatment

  • Have discontinued all previous treatments for cancer

  • Have adequate organ function

  • Have a life expectancy of at least 8 weeks

Participants Must Not:

  • Be pregnant or breastfeeding

  • Have a serious infection

  • Have a serious and/or uncontrolled medical condition(s)

  • Have had any other cancer within 3 years of enrollment (with some exceptions)

  • Have received prior anti-GD2 (such as dinutuximab) during induction/first phase of treatment (anti-GD2 post-consolidation is allowed)

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Take the Next Step

Complete this Lilly Trial Match questionnaire to find out if this clinical trial may be a good fit for you, or a loved one.
When you press Start Lilly Trial Match, you will answer questions about relevant medical conditions and treatment history. The answers will be compared to some of the key criteria for this trial, called inclusion and exclusion criteria.

If your responses show that the trial may be a good fit, you can:
  • Select which clinical trial site works best for you.
  • Share your details and questionnaire directly with site(s) that allow this.
  • Get contact details for the site(s) of your choice.

Completing the Trial Match questionnaire doesn’t mean that you will be enrolled in a study. There may be more eligibility criteria for the study which are assessed by the Lilly clinical team.

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