Completed Enrollment

A Study of Abemaciclib (LY2835219) in Participants With Non-Small Cell Lung Cancer or Breast Cancer

I3Y-MC-JPCE -

The main purpose of this study is to evaluate the safety and efficacy of abemaciclib in combination with pembrolizumab in participants with advanced non-small cell lung cancer (NSCLC) or hormone receptor positive (HR+), human epidermal growth factor receptor negative (HER2-) breast cancer.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Breast Cancer, Non-Small Cell Lung Cancer
What the trial is testing?
Abemaciclib, Pembrolizumab
Could I receive a Placebo?
No
Enrollment Goal
100
Trial Dates
Nov 14, 2016 - Dec 2024
How long will I be in the trial?
Your participation could last up to 6 months depending on how you and your tumor respond.
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participant must have a stage IV diagnosis of one of the following: KRAS mt, PD-L1+ NSCLC, squamous NSCLC or HR+, HER2, metastatic breast cancer

  • Participant must be willing and able to provide tumor tissue both prior to treatment and after treatment initiation

  • Participant must have discontinued all previous treatments for cancer and recovered from the acute effects of therapy

Participants Must Not:

  • Participant must not have a history of interstitial lung disease or pneumonitis

  • Participant must not have a history of or active autoimmune disease, or other syndrome that requires systemic steroids or autoimmune agents for the past 2 years

  • Participant must not have received a live vaccination within 30 days of study start

  • Participant must not have received prior treatment with an anti PD-1, anti-programmed death ligand 1 (PD-L1), or anti cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) agent

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Clinical Trial Resources

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