A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancer

I8S-MC-JUAB -

The purpose of this study is to determine the safety of an extracellular signal regulated kinase (ERK1/2) inhibitor LY3214996 administered alone or in combination with other agents in participants with advanced cancer.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Advanced Cancer, Colorectal Cancer, Melanoma, Non-small Cell Lung Cancer
What the trial is testing?
Midazolam, Abemaciclib, Nab-paclitaxel, Cetuximab, Encorafenib, LY3214996
Could I receive a Placebo?
No
Enrollment Goal
210
Trial Dates
Sep 29, 2016 - Oct 24, 2022
How long will I be in the trial?
Your participation may continue for as long as you and your study doctor feel that you are benefiting from the study treatment.
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participant must have advanced, unresectable or metastatic cancer (solid tumors)

Participants Must Not:

  • Participant must not have known HIV infection or hepatitis A, B, or C

  • Participant must not have current blood cancers, acute or chronic leukemia

  • Participant must not have previously completed or withdrawn from this study or any other study investigating an ERK1/2 inhibitor - Female participant must not be pregnant, breastfeeding, or planning to become pregnant

  • Part C: have serious and/or uncontrolled preexisting medical condition(s) that, in the judgment of the investigator, would preclude participation in this study, including interstitial lung disease (ILD) or severe dyspnea at rest or requiring oxygen therapy

  • Part C4 NRAS Melanoma: have previously completed or withdrawn from a study investigating a MEK inhibitor

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Clinical Trial Resources

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Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.