Terminated

A Study of LY3381916 Alone or in Combination With LY3300054 in Participants With Solid Tumors

I9L-MC-JZCA - ClinicalTrials.gov - NCT03343613

The purpose of this study is to evaluate the safety of the study drug LY3381916 administered alone or in combination with anti-programmed cell death ligand 1 (PD-L1) checkpoint antibody (LY3300054).
How long will I be in the trial?
Your participation in this trial could last up to 24 months, depending on your cancer type and how you and your tumor respond.
Email
Terminated

A Study of LY3381916 Alone or in Combination With LY3300054 in Participants With Solid Tumors

I9L-MC-JZCA - ClinicalTrials.gov - NCT03343613

The purpose of this study is to evaluate the safety of the study drug LY3381916 administered alone or in combination with anti-programmed cell death ligand 1 (PD-L1) checkpoint antibody (LY3300054).
How long will I be in the trial?
Your participation in this trial could last up to 24 months, depending on your cancer type and how you and your tumor respond.
Email

Key Requirements

Age :

18+

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participants must have a diagnosis of cancer (solid tumor) that has spread to other parts of the body

Participants must be willing to provide required, newly acquired tumor biopsies (doctor removes a small amount of tissue)

Participants must NOT

Participants must not have cancer that has spread to the brain

Participants must not have an HIV infection or hepatitis B or C

Participants must not have previously received an indoleamine- 2,3-dioxygenase (IDO) inhibitor

Participants must not have an active autoimmune disease or currently require immunosuppression of >10 milligrams of prednisone or equivalent per day

Participants must not have lung disease or inflammation of the lungs or a history of lung inflammation that required steroids

Trial Summary

Conditions the trial is for

Solid Tumor

What the trial is testing?

LY3381916, LY3300054

Could I receive a Placebo?

no

Enrollment Goal

290

Trial Dates

November 2017 - May 2020

Trial Phase

1

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participants must have a diagnosis of cancer (solid tumor) that has spread to other parts of the body

Participants must be willing to provide required, newly acquired tumor biopsies (doctor removes a small amount of tissue)

Participants must NOT

Participants must not have cancer that has spread to the brain

Participants must not have an HIV infection or hepatitis B or C

Participants must not have previously received an indoleamine- 2,3-dioxygenase (IDO) inhibitor

Participants must not have an active autoimmune disease or currently require immunosuppression of >10 milligrams of prednisone or equivalent per day

Participants must not have lung disease or inflammation of the lungs or a history of lung inflammation that required steroids

Trial Summary

Conditions the trial is for

Solid Tumor

What the trial is testing?

LY3381916, LY3300054

Could I receive a Placebo?

no

Enrollment Goal

290

Trial Dates

November 2017 - May 2020

Trial Phase

1

Not the right fit? Sign up to receive updates on new trials.

Trial Locations

Hide locations not currently recruiting

Enter your postal code to see sites near you

Solid Tumor Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?