Recruiting
A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer
J2G-MC-JZJC - ClinicalTrials.gov - NCT04194944
The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body.
How long will I be in the trial?
Your participation in this trial could last approximately 24 months, depending on your cancer type and how you and your tumor respond.
Recruiting
A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer
J2G-MC-JZJC - ClinicalTrials.gov - NCT04194944
The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body.
How long will I be in the trial?
Your participation in this trial could last approximately 24 months, depending on your cancer type and how you and your tumor respond.
Key Requirements
Age :
18+
Sex:
All
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
18+
Sex
All
Participants must
Participants must have advanced/metastatic non-squamous non-small cell lung cancer (NSCLC) that cannot be treated with surgery or radiation therapy
Participants must have a RET gene fusion and sufficient tumor tissue available for confirmatory testing
Participants must be in fair to good health and not have another serious medical condition
Participants must not have had prior chemotherapy for metastatic lung cancer. Chemotherapy in the adjuvant/neoadjuvant setting is permitted
Participants must not have disease that has spread to the brain and is causing symptoms
Participants must be able to swallow capsules
Participants must be willing to use highly effective contraception during the study
Participants must NOT
Participants must not have a heart condition that puts you at risk for abnormal heart rhythms
Trial Summary
Conditions the trial is for
Non-small Cell Lung Cancer
What the trial is testing?
Selpercatinib, Carboplatin, Cisplatin, Pemetrexed, Pembrolizumab
Could I receive a Placebo?
no
Enrollment Goal
400
Trial Dates
March 2020 - April 2026
Trial Phase
3
Enter your postal code to find the nearest site
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
18+
Sex
All
Participants must
Participants must have advanced/metastatic non-squamous non-small cell lung cancer (NSCLC) that cannot be treated with surgery or radiation therapy
Participants must have a RET gene fusion and sufficient tumor tissue available for confirmatory testing
Participants must be in fair to good health and not have another serious medical condition
Participants must not have had prior chemotherapy for metastatic lung cancer. Chemotherapy in the adjuvant/neoadjuvant setting is permitted
Participants must not have disease that has spread to the brain and is causing symptoms
Participants must be able to swallow capsules
Participants must be willing to use highly effective contraception during the study
Participants must NOT
Participants must not have a heart condition that puts you at risk for abnormal heart rhythms
Trial Summary
Conditions the trial is for
Non-small Cell Lung Cancer
What the trial is testing?
Selpercatinib, Carboplatin, Cisplatin, Pemetrexed, Pembrolizumab
Could I receive a Placebo?
no
Enrollment Goal
400
Trial Dates
March 2020 - April 2026
Trial Phase
3
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Trial Locations
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