Recruiting

A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

J2G-MC-JZJC - ClinicalTrials.gov - NCT04194944

The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body.
How long will I be in the trial?
Your participation in this trial could last approximately 24 months, depending on your cancer type and how you and your tumor respond.
Email
Recruiting

A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

J2G-MC-JZJC - ClinicalTrials.gov - NCT04194944

The reason for this study is to see if the study drug selpercatinib compared to a standard treatment is effective and safe in participants with rearranged during transfection (RET) fusion-positive non-squamous non-small cell lung cancer (NSCLC) that has spread to other parts of the body.
How long will I be in the trial?
Your participation in this trial could last approximately 24 months, depending on your cancer type and how you and your tumor respond.
Email

Key Requirements

Age :

18+

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participants must have advanced/metastatic non-squamous non-small cell lung cancer (NSCLC) that cannot be treated with surgery or radiation therapy

Participants must have a RET gene fusion and sufficient tumor tissue available for confirmatory testing

Participants must be in fair to good health and not have another serious medical condition

Participants must not have had prior chemotherapy for metastatic lung cancer. Chemotherapy in the adjuvant/neoadjuvant setting is permitted

Participants must not have disease that has spread to the brain and is causing symptoms

Participants must be able to swallow capsules

Participants must be willing to use highly effective contraception during the study

Participants must NOT

Participants must not have a heart condition that puts you at risk for abnormal heart rhythms

Trial Summary

Conditions the trial is for

Non-small Cell Lung Cancer

What the trial is testing?

Selpercatinib, Carboplatin, Cisplatin, Pemetrexed, Pembrolizumab

Could I receive a Placebo?

no

Enrollment Goal

400

Trial Dates

March 2020 - April 2026

Trial Phase

3

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participants must have advanced/metastatic non-squamous non-small cell lung cancer (NSCLC) that cannot be treated with surgery or radiation therapy

Participants must have a RET gene fusion and sufficient tumor tissue available for confirmatory testing

Participants must be in fair to good health and not have another serious medical condition

Participants must not have had prior chemotherapy for metastatic lung cancer. Chemotherapy in the adjuvant/neoadjuvant setting is permitted

Participants must not have disease that has spread to the brain and is causing symptoms

Participants must be able to swallow capsules

Participants must be willing to use highly effective contraception during the study

Participants must NOT

Participants must not have a heart condition that puts you at risk for abnormal heart rhythms

Trial Summary

Conditions the trial is for

Non-small Cell Lung Cancer

What the trial is testing?

Selpercatinib, Carboplatin, Cisplatin, Pemetrexed, Pembrolizumab

Could I receive a Placebo?

no

Enrollment Goal

400

Trial Dates

March 2020 - April 2026

Trial Phase

3

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Trial Locations

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Non-small Cell Lung Cancer Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?