Active not recruiting

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

I8F-MC-GPGL - ClinicalTrials.gov - NCT03987919

The reason for this study is to compare the effect of the study drug tirzepatide to semaglutide on blood sugar levels in participants with type 2 diabetes.
How long will I be in the trial?
The study will last approximately 47 weeks and may include about 12 visits.
Email
Active not recruiting

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes

I8F-MC-GPGL - ClinicalTrials.gov - NCT03987919

The reason for this study is to compare the effect of the study drug tirzepatide to semaglutide on blood sugar levels in participants with type 2 diabetes.
How long will I be in the trial?
The study will last approximately 47 weeks and may include about 12 visits.
Email

Key Requirements

Age :

18+

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participant must have type 2 diabetes mellitus (T2DM)

Participant must have HbA1c between >7.0% and <10.5%

Participant must be on stable treatment dose of metformin

Participant must be of stable weight

Participants must NOT

Participant must not have type 1 diabetes

Participant must not have pancreatitis

Participant must not have disorders with slowed emptying of the stomach contents, or have had any stomach surgeries for the purpose of weight loss

Participant must not have a personal or family history of medullary thyroid carcinoma or personal history of multiple endocrine neoplasia syndrome type 2

Participant must not have had a heart attack stroke, or hospitalization for congestive heart failure in the past 2 months

Participant must not have been taking weight loss drugs including over-the-counter medications during the last 3 months

Trial Summary

Conditions the trial is for

Adult Type 2 Diabetes

What the trial is testing?

Tirzepatide, Semaglutide

Could I receive a Placebo?

no

Enrollment Goal

1872

Trial Dates

July 2019 - February 2021

Trial Phase

3

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participant must have type 2 diabetes mellitus (T2DM)

Participant must have HbA1c between >7.0% and <10.5%

Participant must be on stable treatment dose of metformin

Participant must be of stable weight

Participants must NOT

Participant must not have type 1 diabetes

Participant must not have pancreatitis

Participant must not have disorders with slowed emptying of the stomach contents, or have had any stomach surgeries for the purpose of weight loss

Participant must not have a personal or family history of medullary thyroid carcinoma or personal history of multiple endocrine neoplasia syndrome type 2

Participant must not have had a heart attack stroke, or hospitalization for congestive heart failure in the past 2 months

Participant must not have been taking weight loss drugs including over-the-counter medications during the last 3 months

Trial Summary

Conditions the trial is for

Adult Type 2 Diabetes

What the trial is testing?

Tirzepatide, Semaglutide

Could I receive a Placebo?

no

Enrollment Goal

1872

Trial Dates

July 2019 - February 2021

Trial Phase

3

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Trial Locations

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Adult Type 2 Diabetes Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?