Completed Enrollment

A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has Not Responded to Treatment

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The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-260. LOXO-260 may be used to treat cancer that has a change in a particular gene (known as the RET gene).

Trial Summary

Age Range
≥12 years
Conditions the trial is for
Lung Cancer, Thyroid Cancer and other Solid Tumors
What the trial is testing?
LOXO-260
Could I receive a Placebo?
No
Enrollment Goal
110
Trial Dates
Mar 23, 2022 - Jun 2025
How long will I be in the trial?
Participation could last up to 24 months (2 years) and possibly longer if the disease does not get worse.
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Be at least 18 years of age. Patients 12 years and older may be allowed trial participation in the second phase of the trial in countries and study sites where approved

  • Have cancer with a change in the RET gene that is advanced and/or has spread to another part(s) of the body

  • Have already taken a type of drug called a RET inhibitor

  • Be well enough to perform their own personal care

  • Have stopped all cancer treatment and have received from the major side effects

  • Have adequate organ function and blood counts, as measured by blood tests

Participants Must Not:

  • Qualify for other cancer treatment proven to cure their disease

  • Have an active infection or any serious medical conditions (other than cancer)

  • Have cancer that has spread to the brain and is causing symptoms

  • Take certain medicines that affect how fast the study drug is broken down in the body

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