Completed Enrollment

A Study of LY3372993 in Participants With Alzheimer's Disease (AD) and Healthy Participants

J1G-MC-LAKB -

The purpose of this study is to evaluate the safety and tolerability of LY3372993 in participants with AD and healthy participants who are of first-generation Japanese origin.

Trial Summary

Age Range
18 - 85 years
Conditions the trial is for
Alzheimer's Disease
What the trial is testing?
LY3372993
Could I receive a Placebo?
Yes
Enrollment Goal
224
Trial Dates
Jul 7, 2020 - Oct 2024
How long will I be in the trial?
Participation could last up to about 61 weeks and may include up to 28 visits to the study center.
Trial Phase
I

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have gradual and progressive changes in memory for at least 6 months

  • Participants must have a family member or close friend who is with the participant at least 10 hours per week and can participate in study appointments

  • Healthy males or females with a body mass index of 18.0 to 32.0 kg/m2, inclusive

  • To qualify as a participant of the first-generation Japanese origin

Participants Must Not:

  • Participants must not have other serious or unstable illnesses

  • Participants must not have magnetic implants or have a fear of being in an enclosed space

  • Participants must not have multiple or severe drug allergies

  • Participants must not have a serious risk for suicide

  • Participants must not drink alcohol heavily or abuse street drugs

  • Partcipants must not have a family history of early onset AD (AD diagnosed prior to 65 years of age)

  • Participants must not have used or intend to use over-the-counter or prescription medication including herbal medications within 14 days prior to dosing

  • Participants must not have a history or presence of significant psychiatric disorders

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Clinical Trial Resources

Alzheimer’s Disease and Memory Loss Research Studies

To learn more about Alzheimer’s, memory loss and clinical trials being carried out in this area, visit our Alzheimer’s Disease Research page.

Learn More

Neurodegenerative Disease Research

To learn more about neurodegenerative diseases and clinical trials being carried out in the area, visit our Neurodegenerative Disease Research page.

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.