Enrolling

Study of LOXO-305 Versus Investigator's Choice (IdelaR or BR) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (BRUIN CLL-321)

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This is a study for participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have already received treatment. The main purpose is to compare pirtobrutinib to other drugs that have already been approved by the United States Food and Drug Administration (US FDA) for CLL/SLL.

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See if You May Qualify

Answer a few questions to see if you meet key criteria for this study.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
What the trial is testing?
Bendamustine, Idelalisib, LOXO-305, Rituximab
Could I receive a Placebo?
No
Enrollment Goal
250
Trial Dates
Mar 9, 2021 - May 2027
How long will I be in the trial?
Participation could last up to four years, and possibly longer, if the disease does not progress.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have chronic lymphocytic leukemia or small lymphocytic lymphoma that requires treatment

  • Have received prior treatment, including with a type of medicine called a BTK inhibitor

  • Be well enough to perform their own personal care

  • Have adequate organ function and blood counts, as measured by blood tests

Participants Must Not:

  • Have cancer that has become very aggressive or has spread to the brain or spinal cord

  • Have serious heart disease

  • Need a blood thinner called warfarin

  • Have any problems absorbing food or medicine taken by mouth

  • Take certain medicines that affect how fast the study drug is broken down in the body

  • Have active infection

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Take the Next Step

Complete this Lilly Trial Connect questionnaire to find out if this clinical trial may be a good fit for you, or a loved one.
When you press Start Lilly Trial Connect, you will answer questions about relevant medical conditions and treatment history. The answers will be compared to some of the key criteria for this trial, called inclusion and exclusion criteria.

If your responses show that the trial may be a good fit, you can:
  • Select which clinical trial site works best for you.
  • Share your details and questionnaire directly with site(s) that allow this.
  • Get contact details for the site(s) of your choice.

Completing the Trial Connect questionnaire doesn’t mean that you will be enrolled in a study. There may be more eligibility criteria for the study which are assessed by the Lilly clinical team.

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