A Study of Abemaciclib (LY2835219) in Participants With Stage IV Squamous Non-small Cell Lung Cancer

The main purpose of this study is to evaluate the effectiveness of the study drug known as abemaciclib versus docetaxel in participants with stage IV squamous non-small cell lung cancer (NSCLC) previously treated with platinum-based chemotherapy.

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Lung Cancer
What the trial is testing?
Abemaciclib, Docetaxel
Could I receive a Placebo?
No
Enrollment Goal
159
Trial Dates
Aug 6, 2015 - Jul 29, 2020
How long will I be in the trial?
You can participate in this study for as long as your study doctor determines that you are benefiting from the study treatment.
Trial Phase
II

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participant must have a confirmed diagnosis of stage IV squamous NSCLC

  • Participant must have progressed during or after platinum-based chemotherapy

  • Participant must be fully active or if restricted in physically strenuous activity should be able to walk and carry out light work, e.g., light house work, office work

  • Participant must agree to use a reliable medically approved method of birth control

Participants Must Not:

  • Participant must not have received prior treatment with docetaxel

  • Participant must not have received prior treatment with any cyclin dependent kinase (CDK) 4 and 6 inhibitor or participated in a clinical trial with a CDK 4 and 6 inhibitor where the treatment administered is not known

  • Participant must not be currently receiving treatment in a clinical trial involving an investigational product or non-approved use of a drug or device

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