The purpose of this study is to find out whether the study drug, LOXO-338, is safe and effective in patients with advanced blood cancer. Patients must have already received standard therapy.
Have B-cell cancer that requires treatment, including chronic lymphocytic leukemia, non-Hodgkin's lymphoma, Waldenström macroglobulinemia, multiple myeloma and AL amyloidosis
Have already had treatment for B-cell cancer
Be well enough to walk and do light work
Have adequate organ function and blood counts, as measured by blood tests
Have recovered from the major side effects of prior cancer treatments
Have active cancer that has spread to the brain or spinal cord
Have active infection
Be taking other cancer treatments
Take certain medicines that affect how fast the study drug is broken down in the body
Have serious heart disease
By volunteering to take part in Leukemia and Lymphoma clinical trials, you may be able to play an important role in the research and development of potential new treatments and medicines. We understand that when you or a loved one take part in a clinical trial, it is a big decision. It is important for you to understand why the research is being carried out and what taking part will mean for you. Learn more about Lilly
Leukemia + Lymphoma Research
Lilly has been involved in cancer research for more than fifty years, working to improve the lives of people living with cancer. Learn more about cancer research at Lilly and how you can make an impact.
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A clinical trial is a scientific study. It helps us learn if a new medicine or treatment works and how it works. Clinical trials can also be called clinical research studies. Learn more about clinical research studies and what to expect when taking part in a clinical trial.