A Study of Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors (PACT)
The main purpose of this study is to evaluate the safety and tolerability of anti-programmed cell death ligand 1 (PD-L1) checkpoint antibody LY3300054 in participants with advanced refractory solid tumors.
Trial Summary
Key Requirements
Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.Participants Must:
Participant must have diagnosis of advanced solid tumor confirmed by histology or cytology
Participants entering the phase 1a dose escalation must submit, if available, an archival tumor tissue sample
Participants participating ONLY in the phase 1b expansion must submit tissue sample from either a newly obtained core or excisional biopsy of a tumor lesion or a recent (3 years since last documented progression of disease.) biopsy
Participants Must Not:
Participant must not have a serious concomitant systemic disorder including HIV, active hepatitis B virus (HBV), active hepatitis C virus (HCV), active autoimmune disorder or disease requiring high dose of steroids
Participant must not have a bowel obstruction or chronic diarrhea
Participant must not have symptomatic or uncontrolled brain metastases, spinal cord compression, or leptomeningeal disease requiring concurrent treatment
Participant must not have received a live vaccine within 30 days before the first dose of study treatment
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Clinical Trial Resources
You will complete the questionnaire on another website.YesNo