Terminated
A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation
J2K-MC-JZKA - ClinicalTrials.gov - NCT04165031
The reason for this study is to see if the study drug LY3499446 is safe and effective in participants with solid tumors with KRAS G12C mutation.
How long will I be in the trial?
Your participation in this trial could last up to 24 months, depending on your cancer type and how you and your tumor respond
Terminated
A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation
J2K-MC-JZKA - ClinicalTrials.gov - NCT04165031
The reason for this study is to see if the study drug LY3499446 is safe and effective in participants with solid tumors with KRAS G12C mutation.
How long will I be in the trial?
Your participation in this trial could last up to 24 months, depending on your cancer type and how you and your tumor respond
Key Requirements
Age :
18+
Sex:
All
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
18+
Sex
All
Participants must
Participants must have diagnosis of a solid tumor with KRAS G12C mutation that did not respond to at least 1 line of standard therapy and has spread to other part(s) of the body
For phase II, participants must be willing to have new tumor tissue biopsies (doctor removes a small amount of tissue) during the study if it does not cause undue risks to health
Participants must be willing to use highly effective birth control
Participants must have adequate organ function
Participants must be able to swallow capsules
Participants must NOT
Participants must not have certain infections such as hepatitis or tuberculosis or HIV that is not well controlled
Participants must not have another serious medical condition including a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months
Participants must not have cancer of the central nervous system that is not stable
Participants must not be pregnant or breastfeeding
Participants must not use herbal supplements
Trial Summary
Conditions the trial is for
Solid Tumor
What the trial is testing?
LY3499446, Abemaciclib, Cetuximab, Erlotinib, Docetaxel
Could I receive a Placebo?
no
Enrollment Goal
230
Trial Dates
November 2019 - October 2020
Trial Phase
1
Enter your postal code to find the nearest site
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
18+
Sex
All
Participants must
Participants must have diagnosis of a solid tumor with KRAS G12C mutation that did not respond to at least 1 line of standard therapy and has spread to other part(s) of the body
For phase II, participants must be willing to have new tumor tissue biopsies (doctor removes a small amount of tissue) during the study if it does not cause undue risks to health
Participants must be willing to use highly effective birth control
Participants must have adequate organ function
Participants must be able to swallow capsules
Participants must NOT
Participants must not have certain infections such as hepatitis or tuberculosis or HIV that is not well controlled
Participants must not have another serious medical condition including a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months
Participants must not have cancer of the central nervous system that is not stable
Participants must not be pregnant or breastfeeding
Participants must not use herbal supplements
Trial Summary
Conditions the trial is for
Solid Tumor
What the trial is testing?
LY3499446, Abemaciclib, Cetuximab, Erlotinib, Docetaxel
Could I receive a Placebo?
no
Enrollment Goal
230
Trial Dates
November 2019 - October 2020
Trial Phase
1
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Trial Locations
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