Terminated

A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation

J2K-MC-JZKA - ClinicalTrials.gov - NCT04165031

The reason for this study is to see if the study drug LY3499446 is safe and effective in participants with solid tumors with KRAS G12C mutation.
How long will I be in the trial?
Your participation in this trial could last up to 24 months, depending on your cancer type and how you and your tumor respond
Email
Terminated

A Study of LY3499446 in Participants With Advanced Solid Tumors With KRAS G12C Mutation

J2K-MC-JZKA - ClinicalTrials.gov - NCT04165031

The reason for this study is to see if the study drug LY3499446 is safe and effective in participants with solid tumors with KRAS G12C mutation.
How long will I be in the trial?
Your participation in this trial could last up to 24 months, depending on your cancer type and how you and your tumor respond
Email

Key Requirements

Age :

18+

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participants must have diagnosis of a solid tumor with KRAS G12C mutation that did not respond to at least 1 line of standard therapy and has spread to other part(s) of the body

For phase II, participants must be willing to have new tumor tissue biopsies (doctor removes a small amount of tissue) during the study if it does not cause undue risks to health

Participants must be willing to use highly effective birth control

Participants must have adequate organ function

Participants must be able to swallow capsules

Participants must NOT

Participants must not have certain infections such as hepatitis or tuberculosis or HIV that is not well controlled

Participants must not have another serious medical condition including a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months

Participants must not have cancer of the central nervous system that is not stable

Participants must not be pregnant or breastfeeding

Participants must not use herbal supplements

Trial Summary

Conditions the trial is for

Solid Tumor

What the trial is testing?

LY3499446, Abemaciclib, Cetuximab, Erlotinib, Docetaxel

Could I receive a Placebo?

no

Enrollment Goal

230

Trial Dates

November 2019 - October 2020

Trial Phase

1

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participants must have diagnosis of a solid tumor with KRAS G12C mutation that did not respond to at least 1 line of standard therapy and has spread to other part(s) of the body

For phase II, participants must be willing to have new tumor tissue biopsies (doctor removes a small amount of tissue) during the study if it does not cause undue risks to health

Participants must be willing to use highly effective birth control

Participants must have adequate organ function

Participants must be able to swallow capsules

Participants must NOT

Participants must not have certain infections such as hepatitis or tuberculosis or HIV that is not well controlled

Participants must not have another serious medical condition including a serious heart condition, such as congestive heart failure, unstable angina pectoris, or heart attack within the last three months

Participants must not have cancer of the central nervous system that is not stable

Participants must not be pregnant or breastfeeding

Participants must not use herbal supplements

Trial Summary

Conditions the trial is for

Solid Tumor

What the trial is testing?

LY3499446, Abemaciclib, Cetuximab, Erlotinib, Docetaxel

Could I receive a Placebo?

no

Enrollment Goal

230

Trial Dates

November 2019 - October 2020

Trial Phase

1

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Trial Locations

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Solid Tumor Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?