Recruiting

A Study of the CD73 Inhibitor LY3475070 Alone or in Combination With Pembrolizumab in Participants With Advanced Cancer

J2I-MC-JZMA - ClinicalTrials.gov - NCT04148937

The reason for this study is to see if the CD73 inhibitor LY3475070 alone or in combination with pembrolizumab is safe and effective in participants with advanced cancer.
How long will I be in the trial?
Your participation in this trial could last up to 2 years, depending on your cancer type and how you and your tumor responds.
Email
Recruiting

A Study of the CD73 Inhibitor LY3475070 Alone or in Combination With Pembrolizumab in Participants With Advanced Cancer

J2I-MC-JZMA - ClinicalTrials.gov - NCT04148937

The reason for this study is to see if the CD73 inhibitor LY3475070 alone or in combination with pembrolizumab is safe and effective in participants with advanced cancer.
How long will I be in the trial?
Your participation in this trial could last up to 2 years, depending on your cancer type and how you and your tumor responds.
Email

Key Requirements

Age :

18+

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participants must have certain types of cancer such as breast cancer, pancreatic cancer, lung cancer, kidney cancer, skin cancer (melanoma), prostate cancer, and ovarian cancer

Participants must have stopped other forms of treatment for the cancer

Participants must be able and willing to provide a sample of the tumor before beginning treatment and a sample during the treatment. For certain tumor types, the result of a test on the tumor sample may exclude the participant from the study

Participants must have progressed through or be intolerant to therapies with known clinical benefit

Participants must NOT

Participants must not be pregnant, and must agree to use birth control

Participants must not have a current untreated tuberculosis, lung disease, heart disease, uncontrolled HIV, autoimmune disease, active hepatitis B or C virus infection or using corticosteroids

Participant must not have cancer that has spread to the brain

Participant must not have received a vaccine within the last 30 days

Participant must not have had bowel obstruction within the last 6 months, or intestinal surgery

Participant must not have an infection that is currently being treated

Trial Summary

Conditions the trial is for

Advanced Cancer

What the trial is testing?

LY3475070, Pembrolizumab

Could I receive a Placebo?

no

Enrollment Goal

150

Trial Dates

January 2020 - December 2022

Trial Phase

1

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participants must have certain types of cancer such as breast cancer, pancreatic cancer, lung cancer, kidney cancer, skin cancer (melanoma), prostate cancer, and ovarian cancer

Participants must have stopped other forms of treatment for the cancer

Participants must be able and willing to provide a sample of the tumor before beginning treatment and a sample during the treatment. For certain tumor types, the result of a test on the tumor sample may exclude the participant from the study

Participants must have progressed through or be intolerant to therapies with known clinical benefit

Participants must NOT

Participants must not be pregnant, and must agree to use birth control

Participants must not have a current untreated tuberculosis, lung disease, heart disease, uncontrolled HIV, autoimmune disease, active hepatitis B or C virus infection or using corticosteroids

Participant must not have cancer that has spread to the brain

Participant must not have received a vaccine within the last 30 days

Participant must not have had bowel obstruction within the last 6 months, or intestinal surgery

Participant must not have an infection that is currently being treated

Trial Summary

Conditions the trial is for

Advanced Cancer

What the trial is testing?

LY3475070, Pembrolizumab

Could I receive a Placebo?

no

Enrollment Goal

150

Trial Dates

January 2020 - December 2022

Trial Phase

1

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Trial Locations

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Advanced Cancer Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?