Recruiting
A Study of the CD73 Inhibitor LY3475070 Alone or in Combination With Pembrolizumab in Participants With Advanced Cancer
J2I-MC-JZMA - ClinicalTrials.gov - NCT04148937
The reason for this study is to see if the CD73 inhibitor LY3475070 alone or in combination with pembrolizumab is safe and effective in participants with advanced cancer.
How long will I be in the trial?
Your participation in this trial could last up to 2 years, depending on your cancer type and how you and your tumor responds.
Recruiting
A Study of the CD73 Inhibitor LY3475070 Alone or in Combination With Pembrolizumab in Participants With Advanced Cancer
J2I-MC-JZMA - ClinicalTrials.gov - NCT04148937
The reason for this study is to see if the CD73 inhibitor LY3475070 alone or in combination with pembrolizumab is safe and effective in participants with advanced cancer.
How long will I be in the trial?
Your participation in this trial could last up to 2 years, depending on your cancer type and how you and your tumor responds.
Key Requirements
Age :
18+
Sex:
All
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
18+
Sex
All
Participants must
Participants must have certain types of cancer such as breast cancer, pancreatic cancer, lung cancer, kidney cancer, skin cancer (melanoma), prostate cancer, and ovarian cancer
Participants must have stopped other forms of treatment for the cancer
Participants must be able and willing to provide a sample of the tumor before beginning treatment and a sample during the treatment. For certain tumor types, the result of a test on the tumor sample may exclude the participant from the study
Participants must have progressed through or be intolerant to therapies with known clinical benefit
Participants must NOT
Participants must not be pregnant, and must agree to use birth control
Participants must not have a current untreated tuberculosis, lung disease, heart disease, uncontrolled HIV, autoimmune disease, active hepatitis B or C virus infection or using corticosteroids
Participant must not have cancer that has spread to the brain
Participant must not have received a vaccine within the last 30 days
Participant must not have had bowel obstruction within the last 6 months, or intestinal surgery
Participant must not have an infection that is currently being treated
Trial Summary
Conditions the trial is for
Advanced Cancer
What the trial is testing?
LY3475070, Pembrolizumab
Could I receive a Placebo?
no
Enrollment Goal
150
Trial Dates
January 2020 - December 2022
Trial Phase
1
Enter your postal code to find the nearest site
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
18+
Sex
All
Participants must
Participants must have certain types of cancer such as breast cancer, pancreatic cancer, lung cancer, kidney cancer, skin cancer (melanoma), prostate cancer, and ovarian cancer
Participants must have stopped other forms of treatment for the cancer
Participants must be able and willing to provide a sample of the tumor before beginning treatment and a sample during the treatment. For certain tumor types, the result of a test on the tumor sample may exclude the participant from the study
Participants must have progressed through or be intolerant to therapies with known clinical benefit
Participants must NOT
Participants must not be pregnant, and must agree to use birth control
Participants must not have a current untreated tuberculosis, lung disease, heart disease, uncontrolled HIV, autoimmune disease, active hepatitis B or C virus infection or using corticosteroids
Participant must not have cancer that has spread to the brain
Participant must not have received a vaccine within the last 30 days
Participant must not have had bowel obstruction within the last 6 months, or intestinal surgery
Participant must not have an infection that is currently being treated
Trial Summary
Conditions the trial is for
Advanced Cancer
What the trial is testing?
LY3475070, Pembrolizumab
Could I receive a Placebo?
no
Enrollment Goal
150
Trial Dates
January 2020 - December 2022
Trial Phase
1
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Trial Locations
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