Completed
A Study of Prexasertib (LY2606368) in Platinum-Resistant or Refractory Recurrent Ovarian Cancer
I4D-MC-JTJN - ClinicalTrials.gov - NCT03414047
The purpose of this study is to evaluate the efficacy and safety of prexasertib in women with ovarian, primary peritoneal, or fallopian tube cancer that did not respond well to chemotherapy or has recurred.
How long will I be in the trial?
Your participation depends on how well your disease responds to the study treatment and how many cycles of treatment you receive. One cycle is 28 days.
Completed
A Study of Prexasertib (LY2606368) in Platinum-Resistant or Refractory Recurrent Ovarian Cancer
I4D-MC-JTJN - ClinicalTrials.gov - NCT03414047
The purpose of this study is to evaluate the efficacy and safety of prexasertib in women with ovarian, primary peritoneal, or fallopian tube cancer that did not respond well to chemotherapy or has recurred.
How long will I be in the trial?
Your participation depends on how well your disease responds to the study treatment and how many cycles of treatment you receive. One cycle is 28 days.
Key Requirements
Age :
18+
Sex:
Female
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
18+
Sex
Female
Participants must
Participants must have advanced ovarian, primary peritoneal or fallopian tube cancer
Participants must have cancer that did not respond well to chemotherapy and must have had the breast cancer gene test
Participants must have adequate organ function
Participants must be able and willing to undergo tumor biopsy before treatment
Participants must NOT
Participants must not have known central nervous system (CNS) cancer or cancer that has spread to the CNS
Participants must not have a history of any of the following: - Abdominal fistula (abnormal opening between the stomach or intestines and the skin) or gastrointestinal perforation (hole in the stomach or intestines) - Abdominal abscess (collection of fluid and puss inside the abdomen) within last 3 months - Bowel blockage within the last 3 months
Participants must not have symptoms of active HIV infection or hepatitis A, B, or C
Participants must not have a serious heart condition
Participants must not have received radiation to the whole pelvis
Participants must not take corticosteroids daily (with the exception of inhaled steroids)
Trial Summary
Conditions the trial is for
Advanced Cancer, Ovarian Cancer
What the trial is testing?
Prexasertib
Could I receive a Placebo?
no
Enrollment Goal
180
Trial Dates
April 2018 - October 2020
Trial Phase
2
Enter your postal code to find the nearest site
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
18+
Sex
Female
Participants must
Participants must have advanced ovarian, primary peritoneal or fallopian tube cancer
Participants must have cancer that did not respond well to chemotherapy and must have had the breast cancer gene test
Participants must have adequate organ function
Participants must be able and willing to undergo tumor biopsy before treatment
Participants must NOT
Participants must not have known central nervous system (CNS) cancer or cancer that has spread to the CNS
Participants must not have a history of any of the following: - Abdominal fistula (abnormal opening between the stomach or intestines and the skin) or gastrointestinal perforation (hole in the stomach or intestines) - Abdominal abscess (collection of fluid and puss inside the abdomen) within last 3 months - Bowel blockage within the last 3 months
Participants must not have symptoms of active HIV infection or hepatitis A, B, or C
Participants must not have a serious heart condition
Participants must not have received radiation to the whole pelvis
Participants must not take corticosteroids daily (with the exception of inhaled steroids)
Trial Summary
Conditions the trial is for
Advanced Cancer, Ovarian Cancer
What the trial is testing?
Prexasertib
Could I receive a Placebo?
no
Enrollment Goal
180
Trial Dates
April 2018 - October 2020
Trial Phase
2
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