Active not recruiting

A Study of Prexasertib (LY2606368) in Platinum-Resistant or Refractory Recurrent Ovarian Cancer

I4D-MC-JTJN - ClinicalTrials.gov - NCT03414047

The purpose of this study is to evaluate the efficacy and safety of prexasertib in women with ovarian, primary peritoneal, or fallopian tube cancer that did not respond well to chemotherapy or has recurred.
How long will I be in the trial?
Your participation depends on how well your disease responds to the study treatment and how many cycles of treatment you receive. One cycle is 28 days.
Email
Active not recruiting

A Study of Prexasertib (LY2606368) in Platinum-Resistant or Refractory Recurrent Ovarian Cancer

I4D-MC-JTJN - ClinicalTrials.gov - NCT03414047

The purpose of this study is to evaluate the efficacy and safety of prexasertib in women with ovarian, primary peritoneal, or fallopian tube cancer that did not respond well to chemotherapy or has recurred.
How long will I be in the trial?
Your participation depends on how well your disease responds to the study treatment and how many cycles of treatment you receive. One cycle is 28 days.
Email

Key Requirements

Age :

18+

Sex:

Female

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

Female

Participants must

Participants must have advanced ovarian, primary peritoneal or fallopian tube cancer

Participants must have cancer that did not respond well to chemotherapy and must have had the breast cancer gene test

Participants must have adequate organ function

Participants must be able and willing to undergo tumor biopsy before treatment

Participants must NOT

Participants must not have known central nervous system (CNS) cancer or cancer that has spread to the CNS

Participants must not have a history of any of the following: - Abdominal fistula (abnormal opening between the stomach or intestines and the skin) or gastrointestinal perforation (hole in the stomach or intestines) - Abdominal abscess (collection of fluid and puss inside the abdomen) within last 3 months - Bowel blockage within the last 3 months

Participants must not have symptoms of active HIV infection or hepatitis A, B, or C

Participants must not have a serious heart condition

Participants must not have received radiation to the whole pelvis

Participants must not take corticosteroids daily (with the exception of inhaled steroids)

Trial Summary

Conditions the trial is for

Advanced Cancer, Ovarian Cancer

What the trial is testing?

Prexasertib

Could I receive a Placebo?

no

Enrollment Goal

180

Trial Dates

April 2018 - June 2021

Trial Phase

2

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

Female

Participants must

Participants must have advanced ovarian, primary peritoneal or fallopian tube cancer

Participants must have cancer that did not respond well to chemotherapy and must have had the breast cancer gene test

Participants must have adequate organ function

Participants must be able and willing to undergo tumor biopsy before treatment

Participants must NOT

Participants must not have known central nervous system (CNS) cancer or cancer that has spread to the CNS

Participants must not have a history of any of the following: - Abdominal fistula (abnormal opening between the stomach or intestines and the skin) or gastrointestinal perforation (hole in the stomach or intestines) - Abdominal abscess (collection of fluid and puss inside the abdomen) within last 3 months - Bowel blockage within the last 3 months

Participants must not have symptoms of active HIV infection or hepatitis A, B, or C

Participants must not have a serious heart condition

Participants must not have received radiation to the whole pelvis

Participants must not take corticosteroids daily (with the exception of inhaled steroids)

Trial Summary

Conditions the trial is for

Advanced Cancer, Ovarian Cancer

What the trial is testing?

Prexasertib

Could I receive a Placebo?

no

Enrollment Goal

180

Trial Dates

April 2018 - June 2021

Trial Phase

2

Not the right fit? Sign up to receive updates on new trials.

Trial Locations

Hide locations not currently recruiting

Enter your postal code to see sites near you

Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?