Active not recruiting

A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated with Idiopathic Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) (PRESENCE)

I7S-MC-HBEH - ClinicalTrials.gov - NCT03305809

A randomized placebo-controlled trial to evaluate the safety and efficacy of three doses of study drug LY3154207 treated for 12 weeks in participants with mild-to-moderate dementia associated with LBD (PDD or DLB).
How long will I be in the trial?
Your participation could last approximately 18 weeks and include 12 visits to the study center.
Email
Active not recruiting

A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated with Idiopathic Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) (PRESENCE)

I7S-MC-HBEH - ClinicalTrials.gov - NCT03305809

A randomized placebo-controlled trial to evaluate the safety and efficacy of three doses of study drug LY3154207 treated for 12 weeks in participants with mild-to-moderate dementia associated with LBD (PDD or DLB).
How long will I be in the trial?
Your participation could last approximately 18 weeks and include 12 visits to the study center.
Email

Key Requirements

Age :

40-85

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

40-85

Sex

All

Participants must

Participant must have dementia

Participant must have Parkinson's Disease or dementia with Lewy bodies

Participants on anti-parkinsonian agents, must be on stable doses for at least 3 weeks prior to entering study

Participants on antidepressant medications, must be on stable doses for at least 3 weeks prior to entering study

Participants on blood pressure lowering medications, must be on stable doses for at least 3 weeks prior to entering study

Male participant must use appropriate contraception. Female participant must not be of childbearing potential

Participant must have a reliable caregiver who is in frequent contact with participant and will accompany participant to select visits

Participants must NOT

Participant must not have a history of stroke in the last 6 months

Participant must not have a current or any previous diagnosis of bipolar disorder, schizophrenia, or other primary psychotic disorder

Participant must not have a history of substance abuse within the past 1 year, and/or substance dependence within the past 1 year, not including caffeine and nicotine

Trial Summary

Conditions the trial is for

Lewy Body Dementia, Parkinson's Disease Dementia

What the trial is testing?

LY3154207

Could I receive a Placebo?

yes

Enrollment Goal

340

Trial Dates

November 2017 - July 2020

Trial Phase

2

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

40-85

Sex

All

Participants must

Participant must have dementia

Participant must have Parkinson's Disease or dementia with Lewy bodies

Participants on anti-parkinsonian agents, must be on stable doses for at least 3 weeks prior to entering study

Participants on antidepressant medications, must be on stable doses for at least 3 weeks prior to entering study

Participants on blood pressure lowering medications, must be on stable doses for at least 3 weeks prior to entering study

Male participant must use appropriate contraception. Female participant must not be of childbearing potential

Participant must have a reliable caregiver who is in frequent contact with participant and will accompany participant to select visits

Participants must NOT

Participant must not have a history of stroke in the last 6 months

Participant must not have a current or any previous diagnosis of bipolar disorder, schizophrenia, or other primary psychotic disorder

Participant must not have a history of substance abuse within the past 1 year, and/or substance dependence within the past 1 year, not including caffeine and nicotine

Trial Summary

Conditions the trial is for

Lewy Body Dementia, Parkinson's Disease Dementia

What the trial is testing?

LY3154207

Could I receive a Placebo?

yes

Enrollment Goal

340

Trial Dates

November 2017 - July 2020

Trial Phase

2

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Trial Locations

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Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?