Completed
A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated with Idiopathic Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) (PRESENCE)
I7S-MC-HBEH - ClinicalTrials.gov - NCT03305809
A randomized placebo-controlled trial to evaluate the safety and efficacy of three doses of study drug LY3154207 treated for 12 weeks in participants with mild-to-moderate dementia associated with LBD (PDD or DLB).
How long will I be in the trial?
Your participation could last approximately 18 weeks and include 12 visits to the study center.
Completed
A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated with Idiopathic Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) (PRESENCE)
I7S-MC-HBEH - ClinicalTrials.gov - NCT03305809
A randomized placebo-controlled trial to evaluate the safety and efficacy of three doses of study drug LY3154207 treated for 12 weeks in participants with mild-to-moderate dementia associated with LBD (PDD or DLB).
How long will I be in the trial?
Your participation could last approximately 18 weeks and include 12 visits to the study center.
Key Requirements
Age :
40-85
Sex:
All
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
40-85
Sex
All
Participants must
Participant must have dementia
Participant must have Parkinson's Disease or dementia with Lewy bodies
Participants on anti-parkinsonian agents, must be on stable doses for at least 3 weeks prior to entering study
Participants on antidepressant medications, must be on stable doses for at least 3 weeks prior to entering study
Participants on blood pressure lowering medications, must be on stable doses for at least 3 weeks prior to entering study
Male participant must use appropriate contraception. Female participant must not be of childbearing potential
Participant must have a reliable caregiver who is in frequent contact with participant and will accompany participant to select visits
Participants must NOT
Participant must not have a history of stroke in the last 6 months
Participant must not have a current or any previous diagnosis of bipolar disorder, schizophrenia, or other primary psychotic disorder
Participant must not have a history of substance abuse within the past 1 year, and/or substance dependence within the past 1 year, not including caffeine and nicotine
Trial Summary
Conditions the trial is for
Lewy Body Dementia, Parkinson's Disease Dementia
What the trial is testing?
LY3154207, Placebo
Could I receive a Placebo?
yes
Enrollment Goal
340
Trial Dates
November 2017 - July 2020
Trial Phase
2
Enter your postal code to find the nearest site
Key Requirements
Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.
Age
40-85
Sex
All
Participants must
Participant must have dementia
Participant must have Parkinson's Disease or dementia with Lewy bodies
Participants on anti-parkinsonian agents, must be on stable doses for at least 3 weeks prior to entering study
Participants on antidepressant medications, must be on stable doses for at least 3 weeks prior to entering study
Participants on blood pressure lowering medications, must be on stable doses for at least 3 weeks prior to entering study
Male participant must use appropriate contraception. Female participant must not be of childbearing potential
Participant must have a reliable caregiver who is in frequent contact with participant and will accompany participant to select visits
Participants must NOT
Participant must not have a history of stroke in the last 6 months
Participant must not have a current or any previous diagnosis of bipolar disorder, schizophrenia, or other primary psychotic disorder
Participant must not have a history of substance abuse within the past 1 year, and/or substance dependence within the past 1 year, not including caffeine and nicotine
Trial Summary
Conditions the trial is for
Lewy Body Dementia, Parkinson's Disease Dementia
What the trial is testing?
LY3154207, Placebo
Could I receive a Placebo?
yes
Enrollment Goal
340
Trial Dates
November 2017 - July 2020
Trial Phase
2
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