Active not recruiting

A Study of LY3023414 in Participants With Advanced Cancer

I6A-MC-CBBA - ClinicalTrials.gov - NCT01655225

The purpose of this study is to find a recommended dose level and schedule of dosing LY3023414 that can safely be taken by participants with advanced or metastatic cancer. The study will also explore the changes to various markers in blood cells and potentially tumor cells. Finally, the study will help document any antitumor activity this drug may have.
How long will I be in the trial?
Your participation could last up to 42 days or longer if you are tolerating the study drug and your study doctor thinks your condition is stable or improving.
Email
Active not recruiting

A Study of LY3023414 in Participants With Advanced Cancer

I6A-MC-CBBA - ClinicalTrials.gov - NCT01655225

The purpose of this study is to find a recommended dose level and schedule of dosing LY3023414 that can safely be taken by participants with advanced or metastatic cancer. The study will also explore the changes to various markers in blood cells and potentially tumor cells. Finally, the study will help document any antitumor activity this drug may have.
How long will I be in the trial?
Your participation could last up to 42 days or longer if you are tolerating the study drug and your study doctor thinks your condition is stable or improving.
Email

Key Requirements

Age :

18+

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participant in Part B4 must have malignant pleural or peritoneal mesothelioma and appropriate candidate for treatment with cisplatin/pemetrexed; no prior systemic chemotherapy

Participant in Part B6 must have squamous NSCLC; documented evidence of an activating molecular aberration of the PI3K/mTOR pathway

Participant in Part B7 must have HR+ abd HER2- breast cancer

Participant may need to undergo a biopsy dependent upon which arm of the study you are in

Participant must be able to swallow capsules

Participant must be reliable and willing to make themselves available for the duration of the study and be willing to follow study procedures

Participants must NOT

Participant must not have known acute or chronic leukemia

Participant must not have insulin-dependent diabetes mellitus or a history of gestational diabetes mellitus

Trial Summary

Conditions the trial is for

Advanced Cancer, Mesothelioma, Metastatic Breast Cancer, Non-small Cell Lung Cancer, Non-Hodgkin's Lymphoma

What the trial is testing?

LY3023414, Midazolam, Fulvestrant, Pemetrexed, Cisplatin, Abemaciclib, Letrozole

Could I receive a Placebo?

no

Enrollment Goal

164

Trial Dates

July 2012 - December 2020

Trial Phase

1

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participant in Part B4 must have malignant pleural or peritoneal mesothelioma and appropriate candidate for treatment with cisplatin/pemetrexed; no prior systemic chemotherapy

Participant in Part B6 must have squamous NSCLC; documented evidence of an activating molecular aberration of the PI3K/mTOR pathway

Participant in Part B7 must have HR+ abd HER2- breast cancer

Participant may need to undergo a biopsy dependent upon which arm of the study you are in

Participant must be able to swallow capsules

Participant must be reliable and willing to make themselves available for the duration of the study and be willing to follow study procedures

Participants must NOT

Participant must not have known acute or chronic leukemia

Participant must not have insulin-dependent diabetes mellitus or a history of gestational diabetes mellitus

Trial Summary

Conditions the trial is for

Advanced Cancer, Mesothelioma, Metastatic Breast Cancer, Non-small Cell Lung Cancer, Non-Hodgkin's Lymphoma

What the trial is testing?

LY3023414, Midazolam, Fulvestrant, Pemetrexed, Cisplatin, Abemaciclib, Letrozole

Could I receive a Placebo?

no

Enrollment Goal

164

Trial Dates

July 2012 - December 2020

Trial Phase

1

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Trial Locations

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Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?