Active not recruiting

A Study of LY3434172, a PD-1 and PD-L1 Bispecific Antibody, in Advanced Cancer

J1E-MC-JZEA - ClinicalTrials.gov - NCT03936959

The main purpose of this study is to evaluate the safety and tolerability of the study drug LY3434172, a PD-1/PD-L1 bispecific antibody, in participants with advanced solid tumors.
How long will I be in the trial?
Your participation in this trial could last up to 12 months, depending on how you and your tumor respond.
Email
Active not recruiting

A Study of LY3434172, a PD-1 and PD-L1 Bispecific Antibody, in Advanced Cancer

J1E-MC-JZEA - ClinicalTrials.gov - NCT03936959

The main purpose of this study is to evaluate the safety and tolerability of the study drug LY3434172, a PD-1/PD-L1 bispecific antibody, in participants with advanced solid tumors.
How long will I be in the trial?
Your participation in this trial could last up to 12 months, depending on how you and your tumor respond.
Email

Key Requirements

Age :

18+

Sex:

All

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participant must have a cancer that did not respond to standard therapy and has spread to another part(s) of the body

Participant must be willing to have new tumor tissue biopsies (doctor removes a small amount of tissue) during the study as long as it does not cause undue risks to health

Participant must be willing to use highly effective birth control

Participants must NOT

Participant must not have certain infections such as hepatitis or tuberculosis or HIV that is not well controlled or received certain types of vaccines in the last 30 days

Participant must not have moderate to severe heart disease or heart problems as a result of exposure to certain chemotherapy

Participant must not have cancer of the central nervous system that is not stable

Participant must not have certain diseases that affect immune system, such as autoimmune vasculitis

Participant must not use high doses or increasing doses of corticosteroids or other drugs to suppress the immune system

Participant must not have disorders of the bowel such as bowel blockage, inflammation of the bowel, surgical removal of large parts of the bowel, or evidence of certain types of lung disease or inflammation

Participant must not be pregnant or breastfeeding

Trial Summary

Conditions the trial is for

Advanced Cancer

What the trial is testing?

LY3434172

Could I receive a Placebo?

no

Enrollment Goal

40

Trial Dates

May 2019 - December 2021

Trial Phase

1

Enter your postal code to find the nearest site

Key Requirements

Use the following checklist to help determine if this trial may be a good fit for you. Place a checkmark next to each criteria that you successfully meet.

Age

18+

Sex

All

Participants must

Participant must have a cancer that did not respond to standard therapy and has spread to another part(s) of the body

Participant must be willing to have new tumor tissue biopsies (doctor removes a small amount of tissue) during the study as long as it does not cause undue risks to health

Participant must be willing to use highly effective birth control

Participants must NOT

Participant must not have certain infections such as hepatitis or tuberculosis or HIV that is not well controlled or received certain types of vaccines in the last 30 days

Participant must not have moderate to severe heart disease or heart problems as a result of exposure to certain chemotherapy

Participant must not have cancer of the central nervous system that is not stable

Participant must not have certain diseases that affect immune system, such as autoimmune vasculitis

Participant must not use high doses or increasing doses of corticosteroids or other drugs to suppress the immune system

Participant must not have disorders of the bowel such as bowel blockage, inflammation of the bowel, surgical removal of large parts of the bowel, or evidence of certain types of lung disease or inflammation

Participant must not be pregnant or breastfeeding

Trial Summary

Conditions the trial is for

Advanced Cancer

What the trial is testing?

LY3434172

Could I receive a Placebo?

no

Enrollment Goal

40

Trial Dates

May 2019 - December 2021

Trial Phase

1

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Trial Locations

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Advanced Cancer Resources

Clinical Trial Participation: What to Expect

Clinical Trial Participation: What to Expect

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug , such as: Is it effective? Is it more effective than another established treatment? Is it safe and/or what are its side effects?