A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin (SURPASS-6)
The purpose of this study is to compare the safety and efficacy of the study drug tirzepatide to insulin lispro (U100) three times a day in participants with type 2 diabetes that are already on insulin glargine (U100), with or without metformin.
Trial Summary
Key Requirements
Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.Participants Must:
Participants must have type 2 diabetes
Participants must have been treated with long acting insulin, once or twice daily with or without metformin, sulfonylureas or dipeptidyl peptidase 4 inhibitors for at least 90 days
Participants must have hemoglobin A1c 7.5% and 11.0%
Participants must be of stable weight
Participants must have a BMI 23 kilograms per meter squared (kg/m2) and 45 kg/m2
Participants Must Not:
Participants must not have type 1 diabetes
Participants must not have pancreatitis
Participants must not have had a heart attack, stroke, or hospitalization for congestive heart failure in the past 2 months
Participants must not have a personal or family history of medullary thyroid carcinoma or personal history of multiple endocrine neoplasia syndrome type 2
Participants must not have been taking weight loss drugs, including over-the-counter medications during the last 3 months
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Clinical Trial Resources
You will complete the questionnaire on another website.YesNo